Search results for "Epo receptor"

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Erythropoietin and the heart: physiological effects and the therapeutic perspective.

2014

Erythropoietin (Epo) has been thought to act exclusively on erythroid progenitor cells. The identification of Epo receptor (EpoR) in non-haematopoietic cells and tissues including neurons, astrocytes, microglia, immune cells, cancer cell lines, endothelial cells, bone marrow stromal cells, as well as cells of myocardium, reproductive system, gastrointestinal tract, kidney, pancreas and skeletal muscle indicates that Epo has pleiotropic actions. Epo shows signals through protein kinases, anti-apoptotic proteins and transcription factors. In light of interest of administering recombinant human erythropoietin (rhEpo) and its analogues for limiting infarct size and left ventricular (LV) remodel…

medicine.medical_specialtyStromal cellCardiotonic AgentsAngiogenesisNeovascularization PhysiologicInflammationerythroid progenitor cellshemic and lymphatic diseasesInternal medicineEpo receptorReceptors ErythropoietinMedicineHumansErythropoietinCardioprotectionMicrogliabusiness.industryHeartErythropoietin receptorErythropoietin; Epo receptor; erythroid progenitor cellsEndocrinologymedicine.anatomical_structureErythropoietinCancer researchAirway RemodelingBone marrowmedicine.symptomCardiology and Cardiovascular Medicinebusinessmedicine.drugInternational journal of cardiology

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